Morphine Enhances Microglial Migration through Modulation of P2X4 Receptor Signaling
نویسندگان
چکیده
منابع مشابه
Morphine enhances microglial migration through modulation of P2X4 receptor signaling.
Opioids, although fundamental to the treatment of pain, are limited in efficacy by side effects including tolerance and hyperalgesia. Using an in vitro culture system, we report that morphine increased microglial migration via a novel interaction between mu-opioid and P2X(4) receptors, which is dependent upon PI3K/Akt pathway activation. Morphine at 100 nm enhanced migration of primary microgli...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2009
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4595-08.2009